Many prostate cancers relapse due to the generation of chemoresistance rendering first-line treatment drugs like paclitaxel (PTX) ineffective.The present study aims to determine the role of miRNAs and Hedgehog (Hh) pathway in chemoresistant prostate cancer and to evaluate the combination therapy using Hh inhibitor cyclopamine (CYA).Studies were con
High penetration level of renewable energy has brought great challenges to operation of power systems, and use of flexible resources (FRs) is becoming increasingly important.Flexibility of Pants power systems can be improved by changing generation arrangements, but the interests of some market participants may be harmed in the process.This study pr
Coffee is a drink that is commonly consumed by Indonesian people.Coffee contains caffeine, cafestol, and kahweol which can increase lipid levels, including increasing triglyceride levels.Triglycerides are substances consisting of glycerol linked to fatty acid groups.The purpose of this study was to describe blood triglyceride levels in coffee addic
The article deals with one of Lentils the striking features of the archaeozoological material from the Bronze Age sites in the Southern Urals, which is expressed in the longitudinal fragmentation of livestock bones.Analysis of archaeozoological collections shows that this feature of bone fragmentation covers all major periods of the Bronze Age and
Our earlier study revealed that STRA6 (stimulated by retinoic acid gene 6) was up-regulated within 3 h of TCR stimulation.STRA6 is the high-affinity receptor for plasma retinol-binding protein (RBP) and mediates cellular vitamin A uptake.We generated STRA6 knockout (KO) mice to assess whether such BODIFYING FOAM MOUSSE up-regulation was critical fo